Research activities

Scientific work

Under the supervision of the head of the department, MD, Professor L.V. Gutikova, the following research works are being carried out: "Develop and implement a method for medical prevention of miscarriage in women with combined gynecological pathology: endometriosis and uterine fibroids in reproductive age" No. 20201836 (2021-2025); "Medical prevention, early diagnosis and treatment of diseases of the female reproductive system", order of the UO "GrSMU" No. 586 (2023-2027).

Under the supervision of Associate Professor, PhD Milosh T.S. the work was completed under the grant of the BRFFR: "Develop a method for medical prevention of cardiovascular disorders in patients with natural and surgical menopause based on biochemical, molecular genetic studies and the use of omega-3 polyunsaturated fatty acids" No. 20212935 (2021-2023).

Under the supervision of Associate Professor, PhD Savonevich E.L., the work was completed under the grants of the BRFFR, RFBR: "Restoration of the function of the BRCA1 gene as a mechanism for the formation of resistance to therapy with platinum drugs" (2016-2018); "New mutations in the genes of hereditary breast and ovarian cancer in patients in the Republic of Belarus" (2020-2022).

International cooperation: the department staff takes an active part in international conferences and congresses of the Russian Federation, Poland, Egypt, France, Italy.

Topics of defended doctoral dissertations:

1. Gutikova L.V. "Lactation dysfunction in women in labor who have had gestosis: pathogenetic aspects, predicted risk, correction and prevention" (2011).

2. Kazhina M.V. "Chronic inflammatory diseases of the female pelvic organs against the background of dysbiotic changes in the genitals and methods of their correction in modern conditions" (2005).

Topics of defended candidate dissertations:

1. Kostsova L.V. "Pregravid preparation of women with early pregnancy loss" (2024).

2. Furs V.V. "Placental disorders: diagnostic and treatment methods" (2019).

3. Ganchar E.P. "Pregnancy planning in metabolic syndrome: clinical, diagnostic and prognostic criteria" (2016).

4. Smoley N.A. "Pregnancy, childbirth and postpartum period management in women with diffuse goiter and gestosis" (2016).

5. Kukharchik Yu.V. "Early pregnancy loss: pathogenetic aspects, correction and prevention" (2014).

6. Khvorik N.V. "Non-infectious liver pathology in pregnant women: clinical and diagnostic criteria, impact on pregnancy and birth outcomes" (2013).

7. Milosh TS "Reproductive function, prooxidant-antioxidant state, oxygen transport function of blood in the "mother-fetus" system in rats under the action of bacterial endotoxin and taurine in the body" (2010).

8. Yanushko TV "Correction of chronic placental insufficiency in pregnant women by the characteristics of metabolic changes in the mother-placenta-fetus system" (2009).

9. Plotsky AR "Diagnostic value of homocysteine ​​​​level for identifying congenital malformations of the fetus" (2008).

10. Gutikova LV "Characteristics of the functional system mother-placenta-fetus in late gestosis taking into account hormones and liposoluble antioxidants" (2004).

11. Gurin A.L. "Clinical and laboratory criteria for the diagnosis of inflammatory diseases of the uterine appendages" (2004).

12. Savonevich E.L. "Clinical significance of early detection of antiphospholipid antibodies in miscarriage" (2004).

13. Kazhina M.V. "Clinical and immunological aspects of the effectiveness of autovaccine therapy for chronic inflammatory diseases of the internal genital organs of women" (1994).

14. Beluga V.B. "Optimization of labor stress in circulatory failure" (1990).

15. Egorova T.Yu. "Specialized assistance in antenatal clinics for pregnant women at high risk of premature birth" (1988).

Monographs:

1. Non-infectious liver pathology in pregnant women /V.M. Tsyrkunov, N.V. Khvorik // - Grodno: GrSMU. 2018. - P. 236.

2. Management of pregnancy, childbirth and the postpartum period in women with diffuse goiter and gestosis / L.V. Gutikova, N.A., Smolej // - Grodno: GrSMU, 2017. - 172 p.

3. Planning pregnancy in metabolic syndrome / E.P. Ganchar, M.V. Kazhina // - Grodno: GrSMU, 2017. - 140 p.

4. Endometrial hyperplasia in women of reproductive age: diagnostics, correction and prevention / L.V. Gutikova, M.A. Pavlovskaya// – Grodno, 2016. – 120 p.

5. Biogenic amines in the genesis of early pregnancy loss / L.V. Gutikova, Yu.V. Kukharchik// – Grodno: GrSMU, 2014. – 160 p.

6. Forecasting, correction and prevention of lactation function disorders in women in labor who have had gestosis / L.V. Gutikova// – Grodno: GrSMU, 2007. – 305 p.

7. Criteria for the severity of late gestosis. Vitamin and hormonal homeostasis in the mother-placenta-fetus system / L.V. Gutikova – Grodno: GGAU, 2005. – 109 p.

Articles in scientific journals:

1. A method for predicting antenatal fetal death / E.P. Ganchar, L.V. Gutikova, A.V. Naumov, E.M. Doroshenko, V.Yu. Smirnov / Journal of Grodno State Medical University. - 2025. - Vol. 23, No. 1. - P.41-48.

2. Convulsive syndrome in the postpartum period. A case from practice / E. P. Ganchar, L.V. Gutikova, V.L. Zverko, I.I. Kuzmich, N.V. Khvorik, L.S. But-Gusaim, V.A. Birkos // Journal of Grodno State Medical University. 2025. Vol. 23, No. 3. P. 278-285. https://doi.org/10.25298/2221-8785-2025-23-3-278-285.

3. Prevention of preeclampsia: current capabilities / E.P. Ganchar, L.V. Gutikova, M.V. Kazhina, E.V. Zukhovitskaya / Reproductive health. Eastern Europe. - 2025. - Vol. 15, No. 4. - P. 450-459.

4. Gutikova, L.V. Pathohistological placenta, placental bed in women who had COVID-19 during pregnancy / L.V. Gutikova, E.P. Ganchar, V.L. Zverko, E.V. Luchko, E.I. Lupachik, E.N. Pashchenko // Protection of motherhood and childhood. - 2024. - No. 2 (42). - P. 55-65.

5. Gutikova, L. V. Risk factors and treatment of premenstrual tension syndrome / L. V. Gutikova, Yu. V. Kuharczyk, M. A. Pavlovskaya // Reproductive health. Eastern Europe. - 2024. - Vol. 14 (1). - P. 14-22.

6. Gutikova, L. V. Rationale for the use and evaluation of the effectiveness of combined hormonal rehabilitation in women after laparoscopic treatment of ovarian cysts / L. V. Gutikova // Reproductive health. Eastern Europe. - 2024. - Vol. 14 (4). - P. 443-450.

7.         Kulak-Bejda, A. Inpact of pregnancy/childbirth on dispositional optimism in the context of risk of depression, mental health status and satisfaction witn life / A. Kulak-Bejda, A. Shpakou, Н.В. Хворик, Л.В. Гутикова, I. Aydin Avci, D.C. Eren, L. Kourkouta,A // Frontiers in Psychiatry. - 2024. - Т.14.- С.1271033.

8.         Kulak Bejda, A. Pregnancy and Childbirth Fear of Women from Poland, Greece, Turkey, Belarys, and Russia / A. Kulak Bejda, L. Kourkouta, A. Tsaloglidou, K. Koukourikos, I. Aydin Avci, D. Celik Eren, A. Snpakou, Н.В. Хворик, Л.В. Гутикова // Journal Clinical Medicine. - 2024. - Vol.13.-  С.3681.

9.         Kukharchyk, Yu.V. The level of biogenic amines in women of reproductive age with uterine fibroids / Yu.V. Kukharchyk, A.V. Kopytich, E.A. Kanishchev, E.I. Rybalko // XI International scientific conference, Paris, 09-10.04.2024. - Paris, 2024. - С.1-2.

10.       Savonevich E.L. Comprehehsive analysis of gene mutations in the population of ovarian cancer patients in Belarus / E.L. Savonevich, N.V. Matveychik, A.P. Sokolenko, E.N. Imyanitov: abstract book Bgicc-2024 // Tumori Journal. - 2024. - Vol. 110. – С.28-29.

11. Stanko, D.E. Non-hormonal approach to the correction of early postmenopausal disorders in women with insomnia / D.E. Stanko, E.E. Dobruk, L.G. Chikker, Yu.I. Voynyush, E.A. Lenets // Reproductive health. Eastern Europe. - 2024. - Vol.14(2). - P.179-188.

12. Ganchar, E.P. Method for predicting preeclampsia / E.P. Ganchar // Reproductive health. Eastern Europe. - 2024. - Vol.14(1). - P.23-33.

13. Ganchar, E.P. Genetic polymorphisms in women with habitual miscarriage. Choice of obstetric tactics / E.P. Ganchar, M.V. Kazhina, L.V. Gutikova, E.V. Zukhovitskaya // Medical news. - 2024. - No. 2. - P. 75-80.

14. Ganchar, E.P. Vitamin D level and VDR gene polymorphism [rs1544410] in complicated pregnancy / E.P. Ganchar, L.V. Gutikova, A.L. Gurin // Reproductive health. Eastern Europe. - 2024.- Vol. 14 (4). - P. 478-490.

15. Ganchar, E.P. Analysis of factors of antenatal fetal death / E.P. Ganchar, L.V. Gutikova, V.L. Zverko, S.N. Kutas, V.P. Popelushko // Medical news. - 2024. - No. 9. - P. 77-82.

16. Ganchar, E.P. Perinatal risk factors for childhood disability / E.P. Ganchar, L.V. Gutikova, V.L. Zverko, O.V. Demina, Yu.S. Ganusko, E.E. Onegin // Protection of motherhood and childhood. - 2024. - No. 2 (42). - P. 11-21.

17. Milosh, T.S. Alternative correction of climacteric symptoms in women with natural or surgical menopause / T.S. Milosh // Medical journal. - 2024. - No. 1. - P. 83-90.

18. Plotsky, A.R. Complicated course of Crohn's disease during pregnancy / A.R. Plotsky, A.V. Shulga, E.M. Semenyuk // Journal of the Grodno State Medical University. - 2024. - V.22(4).- P.360-366.

19. Smoley, N.A. Clinical and diagnostic algorithm and tactics of management in case of suspected ectopic pregnancy / N.A. Smoley // Reproductive health. Eastern Europe. - 2024. - V.14(3).- P.366-379.

20. Gutikova, L.V. Prevention of endometriosis development in patients with dysmenorrhea by using combined hormonal contraceptives containing ethinyl estradiol and desogestrel, with an assessment of changes in the hemostasis system / L.V. Gutikova, M.A. Pavlovskaya Reproductive health. Eastern Europe.- 2023.- V.13 (1).- P.34-40.

21. Gutikova, L.V. Efficiency of prolonged steroid therapy for adenomyosis / L.V. Gutikova, M.A. Pavlovskaya // Recipe. - 2023. - Vol. 26 (2). - P. 271-277.

22. Ganchar, E.P. The problem of aspirin resistance in obstetrics / E.P. Ganchar, M.V. Kazhina, L.V. Gutikova, E.V. Zukhovitskaya // Reproductive health. Eastern Europe. - 2023. - Vol. 13 (1). - P. 34-40.

23. Ganchar, E.P. Metabolic profile of free amino acids during pregnancy complicated by COVID-19 / E.P. Ganchar, L.V. Gutikova, A.V. Naumov // Journal of the Grodno State Medical University.- 2023.- Vol. 21 (2).- P. 124-132.

24. Ganchar, E.P. Molecular predictors of fetal growth retardation / E.P. Ganchar // Reproductive health. Eastern Europe.- 2023.- Vol. 13 (4).- P. 346-357.

25. Kostsova, L.V. Method for determining the risk of developing reproductive loss in the first trimester of pregnancy / L.V. Kostsova // Problems of health and ecology.- 2023.- Vol. 20, No. 1.- P. 41-47.

26. Kostyakhin, A.E. Comparative analysis of methods of suturing the vaginal stump during laparoscopic hysterectomy / A.E. Kostyakhin, N.A. Smoley, L.V. Gutikova // Reproductive health. Eastern Europe. - 2023. - Vol. 13 (6). - P. 551-557.

27. Kukharchik, Yu. V. Evaluation of expression of steroid hormone receptors in women of reproductive age with recurrent uterine fibroids / Yu. V. Kukharchik, L. V. Gutikova, A. V. Shulga // Modern perinatal medical technologies in solving problems of demographic security: collection of scientific papers. - Minsk, 2023. - P. 130-134.

28. Novitskaya, T. V. Effect of nitric oxide, serum and intracellular magnesium on pregnancy outcome in patients with undifferentiated connective tissue dysplasia / T. V. Novitskaya, T. Yu. Egorova, V. G. Vakulchik // Reproductive health. Eastern Europe.- 2023.- Vol. 13 (1).- P. 50-58

29. Novitskaya, T.V. Comparative assessment of the course and outcomes of pregnancy in patients with undifferentiated connective tissue dysplasia using conventional and personalized pregravid preparation / T.V. Novitskaya, T.Yu. Egorova, V.G. Vakulch Journal of the Grodno State Medical University.- 2023.- Vol. 21 (2).- P. 161-166.

30. Pavlovskaya, M.A. Recurrence of ovarian endometriosis: clinical and pathogenetic features / M.A. Pavlovskaya, L.V. Gutikova, Yu.V. Kukharchik, A.V. Shulga // Reproductive health. Eastern Europe.- 2023.- Vol. 13 (2).- P. 148-156.

31. Stanko, D.E. Criteria for the diagnosis of a recurrent form of infectious non-inflammatory disease of the vagina in women of reproductive age / D.E. Stanko, L.V. Gutikova // Reproductive health. Eastern Europe. - 2023. - Vol. 13 (4). - P. 588-598.

32. Smoley, N.A. Differentiated approach to the diagnosis and treatment of obstetric bleeding in ectopic pregnancy: a case from practice / N.A. Smoley, N.V. Khvorik, Yu.A. Zhurun ​​// Journal of the Grodno State Medical University. - 2023. - Vol. 21 (3). - P. 299-303.

33. Stanko, D.E. Modern approach to assessing the quality of life of women with recurrent bacterial vaginosis in the process of complex treatment / D.E. Stanko, E.P. Stanko, S.A., Igumnov // Mental health.- 2023.- Vol. 18 (3).- P. 16-27.

34. Ganchar, E.P. Pathohistology of the placenta in fetal growth retardation after COVID-19 infection / E.P. Ganchar, L.V. Gutikova, V.L. Zverko, E.V. Luchko, E.I. Lupachik, E.N. Pashchenko // Medical news.- 2022.- No. 11.- P. 59-65

35. Novitskaya, T.V. Undifferentiated connective tissue dysplasia as a risk factor for gestational complications / T.V. Novitskaya // Journal of the Grodno State Medical University.- 2022.- Vol. 20 (6).- P. 637-641

36. Pavlovskaya, M.A. Matrix metalloproteinases in the genesis of external genital endometriosis / M.A. Pavlovskaya // Reproductive health. Eastern Europe. - 2022. - Vol. 12 (6). - P. 629-635.

37. Additional education of adults in medical fields / A.R. Plotsky // Healthcare. - 2021, No. 1. - P. 21 - 23.

38. Prevention of recurrence of genital endometriosis in the postpartum period / L.V. Gutikova, M.A. Pavlovskaya // "Recipe", 2021, Vol. 24, No. 1. - P. 43-48.

39. Hypergonadotropic ovarial insufficiency in women of late reproductive age / N. Khvoryk, Hamed Asaad // Medical Sciences Pulse. - 2020. - Vol. 14 (1) - P. 10-14.

40. Clinical and diagnostic principles of pregnancy management in diffuse endemic goiter / N.A. Smoley // Reproductive health. Eastern Europe. - 2020. - Vol. 10 (1). - P. 38-49.

41. Casuistic cases of ectopic pregnancy / N.A. Smoley, T.V. Yanushko, A.E. Kostyakhin // Medical aspects of women's health. - 2020. - No. 4-5 (133-134). - P. 43-49.

42. Analysis of the frequency of cesarean sections according to the Robson classification / L.V. Gutikova, Yu.V. Kukharchik, V.L. Zverko, E.N. Pashchenko, D.V. Yushkevich // Reproductive health. Eastern Europe. 2020.- V. 10 (2). - P. 149-154.

43. Organizational and clinical aspects of artificial termination of pregnancy for medical reasons from the fetus / L.V. Gutikova, L.N. Keda // Healthcare. 2020. - V. 12. – P. 20-30.

44.       Serotonin and products of its degradation as predictor of noncarrying pregnancy in the I trimester / J. Kukharchik, L. Gutikova // The 20th international Students` Scientific Conference for students and young doctors, Gdansk, 19-21 april 2012. – Gdansk, 2012. – P. 64.

45.       Treatment of pregnant women with thyroid gland diseases / N.A. Liakhnovich, L. Gutikova / Nauka w świecie wspόtczesnym: Zbiόr raportόw naukowych. Wykonane na materiałach Miedzynarodowej Naukowi-Praktycznej Konferencij, Łόdź, 29-31.05.2013 r. – Łόdź, 2013. – S. 82-85.

46.       Tactics of maintaining of patients with hyperplasia of endometrium at reproductive age / M. Paulouskaya, L. Hutsikava // 10-th Congress Of the European Society of Gynecology Congrès de la Société Européenne de Gynécologie, Square-Brussels, 18-21 September 2013. – Brussels, 2013. – S. 795.

47.       Congenital Letterer-Siwe disease / A.Plotski, E.Lupachik, V.Kononov, S.Sementsova, E.Smirnova // Archives of Perinatal Medicine. – 2013. – Vol. 19, № 1. – Р. 55-57.

48.       Endometriosis of Postoperative Scar [Online First] / Andrei Plotski (July 26th 2019). IntechOpen, DOI: 10.5772/intechopen.88246. Available from July 26th 2019. Р. 41 – 51.

49.       Study of expression of vegf and Ki-67 in perimenopausal women with uterine myoma / Y. Kukharchyk // 15 tn Warsaw International Medical Congress: abstract book, Warsaw, 9-12 May, 2019.- Warsaw, 2019.-  С.225

50.       Receptor Status of Women with Uterine Fibroids and Adenomyosis / L.V. Gutikova, Y.V. Kukharchyk, M.A. Pavlovskaya // EC Gynaecology. – 2020. – 9.7. – P. 10-16.

Textbooks:

1. Obstetrics: a manual for students studying in the specialty 1-79 01 01 "General Medicine", 1-79 01 02 "Pediatrics", 1-79 01 05 "Medical and Psychological Care 1-79 01 04 "Medical and Diagnostic Care" with the stamp of the educational and methodological association for higher medical and pharmaceutical education of the Republic of Belarus / L.V. Gutikova, T.Yu. Egorova, A.R. Plotsky, E.P. Ganchar et al. - Grodno: GrSMU, 2023. - 432 p.

2. Gynecology: a manual for students studying in the specialty 1-79 01 01 "General Medicine", 1-79 01 02 "Pediatrics", 1-79 01 05 "Medical and Psychological Care 1-79 01 04 "Medical and Diagnostic Care" with the stamp of the educational and methodological association for higher medical and pharmaceutical education of the Republic of Belarus L.V. Gutikova, N.V. Khvorik, E.P. Ganchar et al. - Grodno: Grodno State Medical University, 2023. - 436 p. 3. Gynecology: a manual for students studying in the specialty 1-79 01 06 "Nursing" with the stamp of the educational and methodological association for higher medical and pharmaceutical education of the Republic of Belarus / L.V. Gutikova, E.P. Ganchar, T.V. Novitskaya - Grodno: GrSMU, 2020. - 445 p.

4. Obstetrics: a manual for students studying in the specialty 1-79 01 06 "Nursing" with the stamp of the educational and methodological association for higher medical and pharmaceutical education of the Republic of Belarus / L.V. Gutikova, E.P. Ganchar, T.V. Novitskaya - Grodno: GrSMU, 2019. - 276 p.

5. Milosh, T.S. Pediatric gynecology: a textbook / T.S. Milosh, L.V. Gutikova; Ministry of Health of the Republic of Belarus, Uo GrSMU, Department of Obstetrics and Gynecology. - Grodno: GrSMU, 2019. - 227 p.

6. Simulation training workshop: a tutorial / L.V. Gutikova, V.B. Beluga, A.L. Gurin et al.; Ministry of Health of the Republic of Belarus, Uo GrSMU, Department of Obstetrics and Gynecology. Grodno, 2018. – 235 p.

7. Extragenital pathology and pregnancy: a tutorial / L.V. Gutikova, T.Yu. Egorova, E.L. Savonevich et al.; Uo GrSMU, Department of Obstetrics and Gynecology. Grodno, 2017. – 159 p.

8. Obstetrics: a tutorial / L.V. Gutikova, V.B. Beluga, A.L. Gurin et al.; Ministry of Health of the Republic of Belarus, Uo GrSMU, Department of Obstetrics and Gynecology. – Grodno, 2016. – 230 p.

9. Gynecology: a manual / L.V. Gutikova, et al.; Ministry of Health of the Republic of Belarus, Uo Grodno State Medical University, Department of Obstetrics and Gynecology. – Grodno, 2016. – 230 p.

10. Case studies in obstetrics and gynecology: a manual for students of the faculty of foreign students with English language training (specialty 1-79 01 01 "General Medicine") / L.V. Gutikova, Yu.V. Kukharchik, M.A. Pavlovskaya; Ministry of Health of the Republic of Belarus, Uo "Grodno State Medical University". un-t", department of obstetrics and gynecology. - Grodno: Grodno State Medical University, 2016. - 115 p.