Grodno State
Themes of the department's research over the past 10 years:
1. Jointly with the Central Research Laboratory and the departments of the university, research was conducted aimed at developing a cytoprotector and corrector of the metabolism of epithelial tissues "taucine" (01.2011 - 12.2019) within the framework of the State Scientific and Technical Program "Pharmaceutical substances and drugs".
2. Interdepartmental research was carried out on the topic of "Hepato- and nephroprotective properties of a combination of zinc with taurine" (state registration No. 20142466 dated 6.10.2014; 2014 - 2018). 3. Departmental research "Analgesic properties of new piperidine derivatives with substitutions in positions 1 and 4" (2017 - 2018).
4. "Study of analgesic, anti-inflammatory and antipyretic properties of new piperidine derivatives with substitutions in positions 1 and 4" (2019-2021).
5. "Anxiolytic and nootropic properties of new piperidine and morpholine derivatives" 2021-2024).
Patents:
1. Antiarrhythmic agent: patent. No. 15165 / K.D. Praliev, V.P. Vdovichenko, O.T. Zhilkibaev. - Published. 09/15/2005.
2. A method for assessing the inhibition index of the coronary vasodilator response to ADP by 8-sulfophenyltheophylline in isolated mouse hearts to assess the adenosine-generating capacity of the heart : patent. BY 20110904 / V. I. Kozlovsky, V. V. Zincuk. - Published. 09.12.2014.
3. A nephroprotective agent for gentamicin nephropathy : patent. BY 19725 / O. N. Basalai, M. I. Bushma, O. A. Borisenok, S. M. Zimatkin, E. Ch. Mikhalchuk, O. V. Baraban, V. M. Sheybak. - Published. 28.09.2015.
4. A remedy for protecting the liver in case of its cholestatic damage : patent. BY 19784 / A.Yu. Pashko, M.I. Bushma, O.A. Borisenok, S.M. Zimatkin, E.Ch. Mikhalchuk, O.V. Baraban, V.M. Sheybak. – Publ. 09.10.2015.
5. Agent for terminal anesthesia: patent. No. 21318 / V.V. Goncharuk, V.P. Vdovichenko, T.A. Korshak, A.L. Buben, K.D. Praliev. – Publ. 08.06.2017.
International cooperation:
Scientific contacts with:
1. Jagiellonian University in Krakow (Poland) – Department of Pharmacology, Jagiellonian Center for Experimental Therapy.
2. Smolensk State Medical University (Russia) – Department of Pharmacology, Department of Clinical Pharmacology.
3. Bekturov Institute of Chemical Sciences (Almaty, Kazakhstan)
Main significant publications over the past 5 years
1. Analysis of the use of the hypotensive drugs according to the questionnare survey of pharmacy visitors in Grodno H.H. Al-Zeyadi, V.I. Kozlovsky, A.V. Tsymbalisty, V.V. Goncharuk. Journal of Grodno State Medical University. - 2020. - Vol. 18, No. 5. - P. 597-601.
2. O. N. Basalai, M. I. Bushma, O. A. Borisenok. Taurine, arginine and melatonin - bioregulators, drugs and potential nephroprotectors // Medical news. – 2021. – No. 8, – P. 5-12.
3. Vasilyuk, A. A. Promising areas of application of piperidine derivatives as structural components of neurotropic drugs / A. A. Vasilyuk, V. I. Kozlovsky // Bulletin of Vitebsk State Medical University. – 2021. – Vol. 20 (2). – P. 8-17
4. Vasilyuk, A. A. Effects of new piperidine derivatives with substitutions at the 1st and 4th positions in naloxone-sensitive analgesia / A. A. Vasilyuk, V. I. Kozlovsky, G. S. Akhmetova // Journal of Grodno State Medical University. – 2021. – Vol. 19 (5). – P. 501-505.
5. Morpholine derivatives in psychopharmacology / V.I. Kozlovsky, M.I. Yakoltsevich // Journal of the GrSMU. - 2022. - Vol. 20, No. 3. - P. 249-254.
6. Kopytich, A. Opinions of doctors regarding the appointment of some innovative cardiac products / A. Kopytich, V.Vdovichenko // The Scientific Her-itafe.- 2022.- Vol. 86-2.- P. 19-20
7. Fedorov, V.N. Problems of classification and characteristics of neurotropic drugs used to treat cerebrovascular disorders / V.N. Fedorov, A.K. Petrovsky, V.P. Vdovichenko, M.N. Zakharov, A.V. Arshinov // Medical ethics.- 2022.- T.10(1).- P.25-33
8. Vdovichenko, V.P. Screening of plant extracts with antiarrhythmic activity / V. P. Vdovichenko, A. V. Kopytich, T. A. Korshak, G.M. Bronskaya, Boroz-nova E.S. // German International Journal of Modern Science – 2022. – N37- P. 41-43
9. Falkovsky A.G. Some epidemiological data concerning colorectal cancer in the Republic of Belarus /A.G. Falkovsky, A.V. Kopytich, A.V. Chepik, A.A. Falkovskaya, I.A. Nazarchik, E.S. Boroznova, V. P. Vdovichenko // German International Journal of Modern Science – 2022. – N43 - P. 23-24
10. Screening of analgesic activity of a number of new piperidine derivatives with substitutions in the 1st and 4th positions A. A. Vasilyuk, V. I. Kozlovsky, V. K. Yu. Herald of Pharmacy. – 2023. – No. 3. – P. 73 – 81.
11. Spirin N. N., Fedorov V. N., Vdovichenko V. P. The place of the oligopeptide H-Met-Glu-His-Phe-Pro-Gly-Pro-OH in the therapy and rehabilitation of patients with ischemic stroke. Korsakov Journal of Neurology and Psychiatry. Special issues.2024;124(8‑2):56‑63.
12. Fedorov, V. N., Korsakov, M. K., Shetnev, A. A., Grechishcheva, O. V.,
Vdovichenko, V. P., Volkhin, N. N., et al. Antirheumatic activity of a derivative of amide of 3-imidazole-substituted-4,5-dihydroisoxazolecarboxylic acid — an inhibitor of proteinase-activated receptor type II // Medical Ethics. 2024. No. 4. P. 32–39. DOI: 10.24075/medet.2024.022
13. Khokhlov A.L., Tyushina A.N., Fedorov V.N., Korsakov M.K., Vdovichen-ko V.P., Shetnev A.A., Popova A.A. Ophthalmic hypotensive activity of new carbonic anhydrase inhibitors from the class of sulfonyl amide derivatives. Bulletin of the Smolensk State Medical Academy. 2024;23(4):19-27. DOI: 10.37903/vsgma.2024.4.3 EDN: CCBPHU
14. Fedorov V.N., Korsakov M.K., Khokhlov A.L., Arshinov A.V., Vdovichen-ko V.P., Leonova O.V., Suleymanov S.Sh. Potential place of PAR2 inhibitors in therapyin the therapy of rheumatoid arthritis. Qualitative clinical practice. 2024;(4):4-14. https://doi.org/10.37489/2588-0519-2024-4-4-14. EDN: HKQCHI
15. Spirin N.N., Fedorov V.N., Vdovichenko V.P., Bykanova M.A., Korsakov M.K. The place of MAO-B inhibitors in the therapy of Parkinson's disease from the point of view of evidence-based medicine: a literature review. Neurology and neurosurgery. Eastern Europe. 2024;14(4):556-566. doi.org/10.34883/PI.2024.14.4.043 UDC 616-009.1-085.2/.3